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Article

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.

The Journal of biological chemistry - 9 Nov 2007

Schmidt Vanessa, Sporbert Anje, Rohe Michael, Reimer Tatjana, Rehm Armin, Andersen Olav M, Willnow Thomas E

Abstract excerpt

SorLA has been recognized as a novel sorting receptor that regulates trafficking and processing of the amyloid precursor protein (APP) and that represents a significant risk factor for sporadic Alzheimer disease. Here, we investigated the cellular mechanisms that control intracellular trafficking...

Read the complete abstract on PubMed

Topics

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Share to Adaptor Proteins, Vesicular Transport
Share to ADP-Ribosylation Factors
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glycosylation

Share to LDL-Receptor Related Proteins

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Source

Identifiers

PMID: 17855360
DOI: 10.1074/jbc.M705073200

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17855360-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.PMID 17855360Read ↗

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