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Article

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.

The Journal of biological chemistry - 9 Nov 2007

Schmidt Vanessa, Sporbert Anje, Rohe Michael, Reimer Tatjana, Rehm Armin, Andersen Olav M, Willnow Thomas E

Abstract excerpt

SorLA has been recognized as a novel sorting receptor that regulates trafficking and processing of the amyloid precursor protein (APP) and that represents a significant risk factor for sporadic Alzheimer disease. Here, we investigated the cellular mechanisms that control intracellular trafficking of sorLA and their relevance for APP processing. We demonstrate that sorLA acts as a retention factor for APP in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17855360
DOI: 10.1074/jbc.M705073200

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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