Article

Informed dimension reduction of clinically-related genome-wide association summary data characterises cross-trait axes of genetic risk

2020-01-15

Abstract excerpt

Integration of genome-wide association study (GWAS) data has been used to generate new hypotheses of biological mechanism, aetiological relationships between traits, or test causality of one factor for another. However, such approaches have typically been limited to pairwise comparisons of traits. We propose a generally applicable method, that exploits ideas from Bayesian genetic fine mapping to define a “lens” th...

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Literature Corpus work: 47386da8-92a6-5e93-b3dd-e5b24c02624e
DOI: 10.1101/2020.01.14.905869

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