Article
Detecting gene-gene interactions from GWAS using diffusion kernel principal components.
BMC bioinformatics - 1 Feb 2022
Walakira Andrew, Ocira Junior, Duroux Diane, Fouladi Ramouna, Moškon Miha, Rozman Damjana, Van Steen Kristel
Abstract excerpt
Genes and gene products do not function in isolation but as components of complex networks of macromolecules through physical or biochemical interactions. Dependencies of gene mutations on genetic background (i.e., epistasis) are believed to play a role in understanding molecular underpinnings of complex diseases such as inflammatory bowel disease (IBD). However, the process of identifying such interactions is...
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