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Article

Protocol for genetic discovery and fine-mapping of multivariate latent factors from high-dimensional traits.

STAR protocols - 19 Dec 2025

Astle William J, Butterworth Adam S, Asimit Jennifer L

Abstract excerpt

High-dimensional traits, like blood cell traits, are often analyzed using univariate genetic analysis approaches, ignoring trait relationships. Here, we present a protocol for using the flashfmZero software for analyses of latent factors that capture variation in observed traits generated by shared underlying biological mechanisms. We describe steps for calculating genome-wide association study (GWAS) summary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41241937
DOI: 10.1016/j.xpro.2025.104198
PMCID: PMC12664022

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