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Article

Lower-order effects adjustment in quantitative traits model-based multifactor dimensionality reduction.

PloS one - 1 Jan 2012

Mahachie John Jestinah M, Cattaert Tom, Lishout François Van, Gusareva Elena S, Steen Kristel Van

Abstract excerpt

Identifying gene-gene interactions or gene-environment interactions in studies of human complex diseases remains a big challenge in genetic epidemiology. An additional challenge, often forgotten, is to account for important lower-order genetic effects. These may hamper the identification of genuine epistasis. If lower-order genetic effects contribute to the genetic variance of a trait, identified statistical...

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Share to Epistasis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

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Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait, Heritable

Source

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Identifiers

PMID: 22242176
DOI: 10.1371/journal.pone.0029594
PMCID: PMC3252336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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