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Article

Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases.

Genome medicine - 25 Nov 2020

Burren Oliver S, Reales Guillermo, Wong Limy, Bowes John, Lee James C, Barton Anne, Lyons Paul A, Smith Kenneth G C, Thomson Wendy, Kirk Paul D W, Wallace Chris

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified pervasive sharing of genetic architectures across multiple immune-mediated diseases (IMD). By learning the genetic basis of IMD risk from common diseases, this sharing can be exploited to enable analysis of less frequent IMD where, due to limited sample size, traditional GWAS techniques are challenging. METHODS: Exploiting ideas from Bayesian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33239102
DOI: 10.1186/s13073-020-00797-4
PMCID: PMC7687775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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