Article
A gene-distal polygenic architecture underlies the dominant axis of human trait covariation
2026-05-29
Abstract excerpt
Genome-wide significant loci explain only part of the heritable signal for most complex traits, leaving a broad sub-significant polygenic background whose organisation is largely uncharacterised. Whether this background is largely diffuse noise or contains coherent structure shared across traits has been difficult to test, because SNP-level effects are noisy and LD-correlated, and conventional cross-trait analyses...
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Identifiers and source
- Literature Corpus work
- 651ebe29-d5c8-52f4-bb09-9341f0be45d1
- DOI
- 10.64898/2026.05.26.728050