Article

Anle138b manifests potent anti-hyperglycemic activity in type 2 diabetic mice expressing hIAPP

2024-08-30

Abstract excerpt

<h4>Aims/Hypothesis</h4> Type 2 diabetes mellitus (T2DM) is a common metabolic disease, characterized by impaired insulin action, often called “insulin resistance”, in conjunction with a decline in insulin secretion by the pancreatic islet beta cells, referred to as “beta cell failure”. Both conditions contribute to causing hyperglycemia, which is the central feature of T2DM. Cytotoxic aggregates of the beta cell...

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Literature Corpus work: 472288ca-907c-51fa-9de4-75bf4ac2f1f1
DOI: 10.1101/2024.08.27.609850

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