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Article

Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus.

Clinical interventions in aging - 1 Jan 2015

Jeong Hye Rin, An Seong Soo A

Abstract excerpt

Human islet amyloid polypeptide (h-IAPP) is a peptide hormone that is synthesized and cosecreted with insulin from insulin-secreting pancreatic β-cells. Recently, h-IAPP was proposed to be the main component responsible for the cytotoxic pancreatic amyloid deposits in patients with type 2 diabetes mellitus (T2DM). Since the causative factors of IAPP (or amylin) oligomer aggregation are not fully understood, this...

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Source

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Identifiers

PMID: 26604727
DOI: 10.2147/CIA.S95297
PMCID: PMC4655906

Genes

IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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