Article
Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?
Diabetologia - 1 Feb 2004
Clark A, Nilsson M R
Abstract excerpt
The role of islet amyloidosis in the onset and progression of Type 2 diabetes remains obscure. Islet amyloid polypeptide is a 37 amino-acid, beta-cell peptide which is co-stored and co-released with insulin. Human islet amyloid polypeptide refolds to a beta-conformation and oligomerises to form i...
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