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Article

Increased Aβ production prompts the onset of glucose intolerance and insulin resistance.

American journal of physiology. Endocrinology and metabolism - 1 Jun 2012

Jiménez-Palomares Margarita, Ramos-Rodríguez Juan José, López-Acosta José Francisco, Pacheco-Herrero Mar, Lechuga-Sancho Alfonso M, Perdomo Germán, García-Alloza Mónica, Cózar-Castellano Irene

Abstract excerpt

Type 2 diabetes (T2D) mellitus and Alzheimer's disease (AD) are two prevalent diseases with comparable pathophysiological features and genetic predisposition. Patients with AD are more susceptible to develop T2D. However, the molecular mechanism linking AD and T2D remains elusive. In this study, we have generated a new mouse model to test the hypothesis that AD would prompt the onset of T2D in mice. To test our...

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Source

Identifiers

PMID: 22414803
DOI: 10.1152/ajpendo.00500.2011

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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