Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin dysfunction and Tau pathology

1 Jan 2014

Abstract excerpt

The neuropathological hallmarks of Alzheimer's disease (AD) include senile plaques of β-amyloid (Aβ) peptides (a cleavage product of the Amyloid Precursor Protein, or APP) and neurofibrillary tangles (NFT) of hyperphosphorylated Tau protein assembled in paired helical filaments (PHF). NFT pathology is important since it correlates with the degree of cognitive impairment in AD. Only a small proportion of AD is due...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroscience and Neuropharmacology Research
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24574966
DOI: 10.3389/fncel.2014.00022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin dysfunction and Tau pathologyPMID 24574966Read ↗

Association Between Type 2 Diabetes Mellitus and Alzheimer's Disease: Common Molecular Mechanism and Therapeutic TargetsSemantic proximity Read ↗

Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular DamagesSemantic proximity Read ↗

Tau deletion promotes brain insulin resistanceSemantic proximity Read ↗

Insulin Resistance and Diabetes Mellitus in Alzheimer’s DiseaseSemantic proximity Read ↗

A Common Pathogenic Mechanism Linking Type-2 Diabetes and Alzheimer's Disease: Evidence from Animal ModelsSemantic proximity Read ↗

Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and InsulinSemantic proximity Read ↗

Alzheimer’s Disease and Type 2 Diabetes Relationships. I. Cellular and Molecular Common Pathological MechanismsSemantic proximity Read ↗

Understanding the link between insulin resistance and Alzheimer’s disease: Insights from animal modelsSemantic proximity Read ↗

Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegenerationSemantic proximity Read ↗

Spotlight on the Pathophysiological Trajectories Linked to Alzheimer’s Disease (AD): Blood-Brain Barrier (BBB); Neuroinflammation; APOE4 Allele and AD- Insulin Resistance (IR) Pathogenic LinkSemantic proximity Read ↗

Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Experimental Induction of Type 2 Diabetes in Aging-Accelerated Mice Triggered Alzheimer-Like Pathology and Memory DeficitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.