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Article

The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets.

Diabetologia - 1 Oct 2016

Meier Daniel T, Entrup Leon, Templin Andrew T, Hogan Meghan F, Mellati Mahnaz, Zraika Sakeneh, Hull Rebecca L, Kahn Steven E

Abstract excerpt

AIMS/HYPOTHESIS: The S20G human islet amyloid polypeptide (hIAPP) substitution is associated with an earlier onset of type 2 diabetes in humans. Studies of synthetic S20G hIAPP in cell-free systems and immortalised beta cells have suggested that this may be due to increased hIAPP amyloidogenicity and cytotoxicity. Thus, using primary islets from mice with endogenous S20G hIAPP expression, we sought to determine...

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Identifiers

PMID: 27393137
DOI: 10.1007/s00125-016-4045-x
PMCID: PMC5026922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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