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Genetic and Pharmacologic Models for Type 1 Diabetes

1 Mar 2013

Abstract excerpt

Abstract Type 1 diabetes (T1D) is characterized by a partial or total insufficiency of insulin. The premiere animal model of autoimmune T cell‐mediated T1D is the NOD mouse. A dominant negative mutation in the mouse insulin 2 gene (Ins2Akita) produces a severe insulin deficiency syndrome without autoimmune involvement, as do a variety of transgenes overexpressed in beta cells. Pharmacologically induced T1D...

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PMID: 24592352
DOI: 10.1002/9780470942390.mo120154

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