Article

BACE1 – but not BACE2 – function is critical for metabolic disorders induced by high-fat diets in C57BL/6N mice

2021-12-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Aims/hypothesis</h4> Beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is required for the production of toxic amyloid peptides and is highly expressed in the brain, but also to a lesser extent in major peripheral organs such as muscle and liver. In contrast, BACE2 is mainly expressed in peripheral tissues and is enriched in pancreatic beta cells, where it regulates beta- cell f...

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Literature Corpus work: 4e88fbdd-1436-594c-b524-b6d442747cb4
DOI: 10.1101/2021.12.20.473491

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