Article

A potential anti-amyloidogenic therapy for type 2 diabetes based on the QBP1 peptide

2025-05-10

Abstract excerpt

The self-assembly and aggregation of human islet amyloid polypeptide (hIAPP, or amylin) into β-sheet-rich structures, such as oligomers and fibrils, are implicated in pancreatic β-cell dysfunction and failure, contributing to the pathogenesis of Type 2 Diabetes (T2D). Consequently, extensive research has focused on identifying inhibitors, particularly short peptides, capable of targeting hIAPP and disrupting its a...

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Literature Corpus work: 0140010c-c959-51bd-9078-c48ff2840ec8
DOI: 10.1101/2025.05.06.652241

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