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Article

The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jul 2021

Dekeryte Ruta, Franklin Zara, Hull Claire, Croce Lorenzo, Kamli-Salino Sarah, Helk Oliver, Hoffmann Philip A, Yang Zhixiang, Riedel Gernot, Delibegovic Mirela, Platt Bettina

Abstract excerpt

AIM: The β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) has been identified as the central initiator of amyloid β (Aβ) generation in the brain, the key hallmark of Alzheimer's disease (AD). However, recent studies provided evidence that BACE1 also plays a crucial role in metabolic regulation, and we have shown that neuronal human BACE1 knock-in mice (PLB4) display type 2 diabetes mellitus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33892080
DOI: 10.1016/j.bbadis.2021.166149

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