Article

Altered GABAergic inhibition in CA1 pyramidal neurons modifies despair-like behavior in mice

2020-02-19

Abstract excerpt

Despair is a common human feeling characterized by the loss of hope and is a core symptom of depressive disorders. However, little is known regarding neural circuits mediating despair and their modulation by antidepressants. Here we show that alterations in inhibitory synaptic transmission in the hippocampus affect behavioral despair in mice. Reduced interneuron density, knockdown of GABA A receptor gamma 2 subun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46fd0c1e-737f-57d9-83e9-33fb95163052
DOI: 10.1101/2020.02.18.953786

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Altered GABAergic inhibition in CA1 pyramidal neurons modifies despair-like behavior in miceDOI 10.1101/2020.02.18.953786Read

Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice.Semantic proximity Read

Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice.Semantic proximity Read

( <i>R,S</i> )-ketamine’s rapid-acting antidepressant effects are modulated by NR2B-containing NMDA receptors on adult-born hippocampal neuronsSemantic proximity Read

Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signalingSemantic proximity Read

Depressive-like behaviors induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiationSemantic proximity Read

Antidepressant actions of ketamine engage cell-specific translation via eIF4E.Semantic proximity Read

Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice.Semantic proximity Read

Identification of multiple genetic loci linked to the propensity for "behavioral despair" in mice.Semantic proximity Read

Loss of phenotype of parvalbumin interneurons in rat prefrontal cortex is involved in antidepressant- and propsychotic-like behaviors following acute and repeated ketamine administration.Semantic proximity Read

mGluR5 in ECCCK to BLA Circuit Modulates Depressive-Like Phenotypes through CCK Signaling.Semantic proximity Read

Deficit of neuronal EAAT2 impairs hippocampus CA3 neuron's activity and may induce depressive like behaviors.Semantic proximity Read

Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors.Semantic proximity Read