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Article

Deficit of neuronal EAAT2 impairs hippocampus CA3 neuron's activity and may induce depressive like behaviors.

Journal of advanced research - 1 Jan 2026

Cheng Ke, Chen Chong, Zhou Qinji, Chen Xiangyu, Xie Peng

Abstract excerpt

INTRODUCTION: Major depressive disorder (MDD) is a severe neuropsychiatric disease that is accompanied by hippocampal dysfunction. Currently, the complex neuronal types and molecules involved in the various hippocampal subfields in patients with depression remain unclear. OBJECTIVES: We focused on the role of hippocampal excitatory amino acid transporter 2 (EAAT2) in chronic stress. METHODS: We studied two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40096942
DOI: 10.1016/j.jare.2025.03.016
PMCID: PMC12766208

Genes

CA3
SLC1A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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