Article
Loss of phenotype of parvalbumin interneurons in rat prefrontal cortex is involved in antidepressant- and propsychotic-like behaviors following acute and repeated ketamine administration.
Molecular neurobiology - 1 Apr 2015
Zhou ZhiQiang, Zhang GuangFen, Li XiaoMin, Liu XiaoYu, Wang Nan, Qiu LiLi, Liu WenXue, Zuo ZhiYi, Yang JianJun
Abstract excerpt
Accumulating evidence has demonstrated that single subanesthetic dose of ketamine exerts rapid, robust, and lasting antidepressant-like effects. Nevertheless, repeated subanesthetic doses of ketamine produce psychosis-like effects with dysfunction of parvalbumin (PV) interneurons. We hypothesized...
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