Hippocampal teneurin-4 knockdown promotes depression-like behavioral phenotypes by disrupting oligodendrocyte differentiation in mice.

doi:10.1016/j.neuropharm.2026.111148

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Article

Hippocampal teneurin-4 knockdown promotes depression-like behavioral phenotypes by disrupting oligodendrocyte differentiation in mice.

Neuropharmacology - 1 Dec 2026

Sugimori Yuichiro, Yano Yusuke, Asano Takashi, Suzuki Seiryu, Kaigawa Tomoya, Yokose Jun, Shigetsura Yuki, Muramatsu Shin-Ichi, Nitta Atsumi

Abstract excerpt

Depression is one of the most prevalent mental disorders worldwide. The limited clinical efficacy of current antidepressants highlights identifying new therapeutic targets. Emerging evidence suggests that dysfunction of oligodendrocyte lineage cells contributes to the pathophysiology of depression. Teneurin-4 (Tenm4), a transmembrane protein that promotes oligodendrocyte differentiation and myelination, has been...

Read the complete abstract on PubMed

Topics

Animals
Oligodendroglia
Cell Differentiation
Hippocampus
Mice
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Depression

Stress, Psychological

Mice, Inbred C57BL

Nerve Tissue Proteins

Phenotype

Gene Knockdown Techniques

Myelin Basic Protein

Membrane Proteins

Source

Open in PubMed

Identifiers

PMID: 42586309
DOI: 10.1016/j.neuropharm.2026.111148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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