Article
Antidepressant actions of ketamine engage cell-specific translation via eIF4E.
Nature - 1 Feb 2021
Aguilar-Valles Argel, De Gregorio Danilo, Matta-Camacho Edna, Eslamizade Mohammad J, Khlaifia Abdessattar, Skaleka Agnieszka, Lopez-Canul Martha, Torres-Berrio Angelica, Bermudez Sara, Rurak Gareth M, Simard Stephanie, Salmaso Natalina, Gobbi Gabriella, Lacaille Jean-Claude, Sonenberg Nahum
Abstract excerpt
Effective pharmacotherapy for major depressive disorder remains a major challenge, as more than 30% of patients are resistant to the first line of treatment (selective serotonin reuptake inhibitors)1. Sub-anaesthetic doses of ketamine, a non-competitive N-methyl-D-aspartate receptor antagonist2,3, provide rapid and long-lasting antidepressant effects in these patients4-6, but the molecular mechanism of these...
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