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Article

Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice.

Scientific reports - 10 Jun 2021

Martini Tomaz, Ripperger Jürgen A, Stalin Jimmy, Kores Andrej, Stumpe Michael, Albrecht Urs

Abstract excerpt

The circadian clock regulates many biochemical and physiological pathways, and lack of clock genes, such as Period (Per) 2, affects not only circadian activity rhythms, but can also modulate feeding and mood-related behaviors. However, it is not known how cell-type specific expression of Per2 contributes to these behaviors. In this study, we find that Per2 in glial cells is important for balancing mood-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34112905
DOI: 10.1038/s41598-021-91770-7
PMCID: PMC8192521

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