Article

A monoclonal antibody raised against human EZH2 cross-reacts with the RNA-binding protein SAFB

2023-04-03

Abstract excerpt

The Polycomb Repressive Complex 2 (PRC2) is a conserved enzyme that tri-methylates Lysine 27 on Histone 3 (H3K27me3) to promote gene silencing. PRC2 is remarkably responsive to the expression of certain long noncoding RNAs (lncRNAs). In the most notable example, PRC2 is recruited to the X-chromosome shortly after expression of the lncRNA Xist begins during X-chromosome inactivation. However, the mechanisms by whi...

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Literature Corpus work: 46fa67a8-f731-5e15-b151-f29c3d52feb6
DOI: 10.1101/2023.04.03.535391

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