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Article

Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells.

Scientific reports - 15 Aug 2017

Pardo Mercedes, Yu Lu, Shen Shihpei, Tate Peri, Bode Daniel, Letney Blake L, Quelle Dawn E, Skarnes William, Choudhary Jyoti S

Abstract excerpt

MYST histone acetyltransferases have crucial functions in transcription, replication and DNA repair and are hence implicated in development and cancer. Here we characterise Myst2/Kat7/Hbo1 protein interactions in mouse embryonic stem cells by affinity purification coupled to mass spectrometry. This study confirms that in embryonic stem cells Myst2 is part of H3 and H4 histone acetylation complexes similar to...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28811661
DOI: 10.1038/s41598-017-08456-2
PMCID: PMC5557939

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