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Article

Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification.

Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 2014

Alekseyenko Artyom A, Gorchakov Andrey A, Kharchenko Peter V, Kuroda Mitzi I

Abstract excerpt

Understanding the composition of epigenetic regulators remains an important challenge in chromatin biology. Traditional biochemical analysis of chromatin-associated complexes requires their release from DNA under conditions that can also disrupt key interactions. Here we develop a complementary approach (BioTAP-XL), in which cross-linking (XL) enhances the preservation of protein interactions and also allows the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24550272
DOI: 10.1073/pnas.1400648111
PMCID: PMC3932854

Genes

AEBP2
JARID2
CBX4
EED
EHMT1
PHF1
PRC1
SUZ12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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