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Article

A tissue-level phenome-wide network map of colocalized genes and phenotypes in the UK Biobank.

Communications biology - 20 Aug 2022

Rocheleau Ghislain, Forrest Iain S, Duffy Áine, Bafna Shantanu, Dobbyn Amanda, Verbanck Marie, Won Hong-Hee, Jordan Daniel M, Do Ron

Abstract excerpt

Phenome-wide association studies identified numerous loci associated with traits and diseases. To help interpret these associations, we constructed a phenome-wide network map of colocalized genes and phenotypes. We generated colocalized signals using the Genotype-Tissue Expression data and genome-wide association results in UK Biobank. We identified 9151 colocalized genes for 1411 phenotypes across 48 tissues....

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PMID: 35987940
DOI: 10.1038/s42003-022-03820-z
PMCID: PMC9392744

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