Article

PHB2 forms a mitochondrial calcium channel that drives Parkinson’s disease

2026-01-13

Abstract excerpt

<title>Abstract</title> <p>Dysregulated mitochondrial Ca2+ influx is a unifying driver of neurodegeneration, compromising neuronal bioenergetics and survival. In Parkinson’s disease (PD), impaired mitochondrial Ca2+ uptake is a decisive trigger for dopaminergic (DA) neuron loss, yet the molecular identity of the responsible channel has remained unresolved. Although the mitochondrial Ca2+ uniporter (MCU) is regard...

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Literature Corpus work: 46bde4dd-cc43-58a9-8f28-1590f9a2b1bc
DOI: 10.21203/rs.3.rs-8380581/v1

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