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Article

Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases.

Nature - 1 Oct 2025

Vinayagam Deivanayagabarathy, Sitsel Oleg, Schulte Uwe, Constantin Cristina E, Oosterheert Wout, Prumbaum Daniel, Zolles Gerd, Fakler Bernd, Raunser Stefan

Abstract excerpt

Tight control of intracellular Ca2+ levels is fundamental as they are used to control numerous signal transduction pathways1. Plasma membrane Ca2+-ATPases (PMCAs) have a crucial role in this process by extruding Ca2+ against a steep concentration gradient from the cytosol to the extracellular space2. Although new details of PMCA biology are constantly being uncovered, the structural basis of the most...

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Identifiers

PMID: 40836084
DOI: 10.1038/s41586-025-09402-3
PMCID: PMC12488499

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