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Article

Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease

12 Jan 2016

Abstract excerpt

The etiology of idiopathic Parkinson's disease (idPD) remains enigmatic despite recent successes in identification of genes (PARKs) that underlie familial PD. To find new keys to this incurable neurodegenerative disorder we focused on the poorly understood PARK14 disease locus (Pla2g6 gene) and the store-operated Ca(2+) signalling pathway. Analysis of the cells from idPD patients reveals a significant deficiency...

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PMID: 26755131
DOI: 10.1038/ncomms10332

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