Article
The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations.
Human molecular genetics - 15 Jul 2016
Gautier Clément A, Erpapazoglou Zoi, Mouton-Liger François, Muriel Marie Paule, Cormier Florence, Bigou Stéphanie, Duffaure Sophie, Girard Mathilde, Foret Benjamin, Iannielli Angelo, Broccoli Vania, Dalle Carine, Bohl Delphine, Michel Patrick P, Corvol Jean-Christophe, Brice Alexis, Corti Olga
Abstract excerpt
Mutations in PARK2, encoding the E3 ubiquitin protein ligase Parkin, are a common cause of autosomal recessive Parkinson's disease (PD). Loss of PARK2 function compromises mitochondrial quality by affecting mitochondrial biogenesis, bioenergetics, dynamics, transport and turnover. We investigated the impact of PARK2 dysfunction on the endoplasmic reticulum (ER)-mitochondria interface, which mediates calcium...
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