Article
Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2.
Molecular cell - 18 Nov 2021
Tillinghast Jordan, Drury Sydney, Bowser Darren, Benn Alana, Lee Kenneth Pak Kin
Abstract excerpt
Mutations in ATP13A2, also known as PARK9, cause a rare monogenic form of juvenile-onset Parkinson's disease named Kufor-Rakeb syndrome and other neurodegenerative diseases. ATP13A2 encodes a neuroprotective P5B P-type ATPase highly enriched in the brain that mediates selective import of spermine ions from lysosomes into the cytosol via an unknown mechanism. Here we present three structures of human ATP13A2 bound...
Topics
- Allosteric Site
- Binding Sites
- Biological Transport
- Brain
- Cryoelectron Microscopy
- Humans
- Ions
- Lysosomes
- Mutation
- Phosphorylation
- Polyamines
- Protein Domains