Article

A Mitochondrial Inside-Out Iron-Calcium Signal Reveals Drug Targets for Parkinson’s Disease

2022-11-01

Abstract excerpt

<h4>Summary</h4> Dysregulated iron or Ca 2+ homeostasis has been reported in Parkinson’s disease (PD) models. Here we discover a connection between these two metals at the mitochondria. Elevation of iron levels causes inward mitochondrial Ca 2+ overflow, through an interaction of Fe 2+ with Mitochondrial Calcium Uniporter. In PD neurons, iron accumulation-triggered Ca 2+ influx across the mitochondrial surfac...

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Literature Corpus work: 4aef0430-a19f-547d-963d-1c29745af755
DOI: 10.1101/2022.10.30.513580

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