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Article

Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models

21 Jan 2024

Abstract excerpt

Mitochondrial calcium (Ca 2+ ) uptake augments metabolic processes and buffers cytosolic Ca 2+ levels; however, excessive mitochondrial Ca 2+ can cause cell death. Disrupted mitochondrial function and Ca 2+ homeostasis are linked to numerous neurodegenerative diseases (NDs), but the impact of mitochondrial Ca 2+ disruption is not well understood. Here, we show that Drosophila models of multiple NDs (Parkinson's,...

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PMID: 38236772
DOI: 10.1016/j.celrep.2024.113681

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