Article

SLP2/prohibitins aggregates and instability of the PHB complex are key elements in <i> CHCHD10 <sup>S59L</sup> </i> -related disease

2021-05-31

Abstract excerpt

CHCHD10 is an ALS/FTD gene, also involved in a large clinical spectrum, that encodes a protein whose precise function within mitochondria is unclear. Here we show that CHCHD10 interacts with the Stomatin-Like Protein 2 (SLP2) to control the stability of the Prohibitin (PHB) complex in the inner mitochondrial membrane. In affected tissues, SLP2 forms aggregates with prohibitins and the instability of the PHB comple...

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Literature Corpus work: 98300457-7f29-564b-b66a-77a9848d891a
DOI: 10.1101/2021.05.31.446377

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