Article

Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2

2021-05-27

Abstract excerpt

<h4>Summary</h4> Mutations in ATP13A2 , also known as PARK9 , cause a rare monogenic form of juvenile onset Parkinson’s disease named Kufor-Rakeb syndrome and other neurodegenerative diseases. ATP13A2 encodes a neuroprotective P5B P-type ATPase highly enriched in the brain that mediates selective import of spermine ions from lysosomes into the cytosol via an unknown mechanism. Here we present three structures...

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Literature Corpus work: d3f03df9-a65d-541e-9289-1b0e4db5a09e
DOI: 10.1101/2021.05.26.445856

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