Article

Genome wide association studies are enriched for interacting genes

2024-10-22

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : With recent advances in single cell technology, high-throughput methods provide unique insight into disease mechanisms and more importantly, cell type origin. Here, we used multi-omics data to understand how genetic variants from genome-wide association studies influence development of disease. We show in principle how to use genetic algorithms with normal,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46bae9a6-aa1e-52c3-80b4-9388c80cbc76
DOI: 10.21203/rs.3.rs-5189487/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome wide association studies are enriched for interacting genesDOI 10.21203/rs.3.rs-5189487/v2Read

A network-based analysis of the cellular and genetic etiology of diseaseSemantic proximity Read

Genetic interactions effects for cancer disease identification using computational models: a review.Semantic proximity Read

Biological networks and GWAS: comparing and combining network methods to understand the genetics of familial breast cancer susceptibility in the GENESIS studySemantic proximity Read

Predictability of Genetic Interactions from Functional Gene ModulesSemantic proximity Read

Nongenic cancer-risk SNPs affect oncogenes, tumor suppressor genes, and immune functionSemantic proximity Read

Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets.Semantic proximity Read

Association weight matrix: a network-based approach towards functional genome-wide association studies.Semantic proximity Read

Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.Semantic proximity Read

High-resolution mapping of cancer cell networks using co-functional interactionsSemantic proximity Read

Interpretable network-guided epistasis detection.Semantic proximity Read

Nongenic cancer-risk SNPs affect oncogenes, tumour-suppressor genes, and immune function.Semantic proximity Read

Gene-Set Enrichment with Mathematical BiologySemantic proximity Read