Article
Association weight matrix: a network-based approach towards functional genome-wide association studies.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Reverter Antonio, Fortes Marina R S
Abstract excerpt
In this chapter we describe the Association Weight Matrix (AWM), a novel procedure to exploit the results from genome-wide association studies (GWAS) and, in combination with network inference algorithms, generate gene networks with regulatory and functional significance. In simple terms, the AWM is a matrix with rows represented by genes and columns represented by phenotypes. Individual {i, j}th elements in the...
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