Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.

Nature methods - 1 May 2013

Laufer Christina, Fischer Bernd, Billmann Maximilian, Huber Wolfgang, Boutros Michael

Abstract excerpt

Genetic interactions influence many phenotypes and can be used as a powerful experimental tool to discover functional relationships between genes. Here we describe a robust and scalable method to systematically map genetic interactions in human cancer cells using combinatorial RNAi and high-throughput imaging. Through automated, single-cell phenotyping, we measured genetic interactions across a broad spectrum of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Automation
Share to Colonic Neoplasms
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Quality Control

Share to RNA Interference

Source

Identifiers

PMID: 23563794
DOI: 10.1038/nmeth.2436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.PMID 23563794Read ↗

Measuring genetic interactions in human cells by RNAi and imaging.Semantic proximity Read ↗

High-resolution mapping of cancer cell networks using co-functional interactionsSemantic proximity Read ↗

The phenotypic landscape of essential human genesSemantic proximity Read ↗

Mapping cancer genetics at single-cell resolution.Semantic proximity Read ↗

Genetic interactions under the microscope.Semantic proximity Read ↗

The phenotypic landscape of essential human genes.Semantic proximity Read ↗

Heterogeneity and Intrinsic Variation in Spatial Genome OrganizationSemantic proximity Read ↗

Expanding TheCellMap.org to visualize a genome-scale genetic interaction network for a human cell lineSemantic proximity Read ↗

A global genetic interaction map of a human cell reveals conserved principles of genetic networksSemantic proximity Read ↗

A global genetic interaction network by single-cell imaging and machine learning.Semantic proximity Read ↗

Morphological map of under- and over-expression of genes in human cellsSemantic proximity Read ↗

Multimodal cell maps as a foundation for structural and functional genomics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.