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Article

Nongenic cancer-risk SNPs affect oncogenes, tumour-suppressor genes, and immune function.

British journal of cancer - 1 Feb 2020

Fagny Maud, Platig John, Kuijjer Marieke Lydia, Lin Xihong, Quackenbush John

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWASes) have identified many noncoding germline single-nucleotide polymorphisms (SNPs) that are associated with an increased risk of developing cancer. However, how these SNPs affect cancer risk is still largely unknown. METHODS: We used a systems biology approach to analyse the regulatory role of cancer-risk SNPs in thirteen tissues. By using data from the...

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Identifiers

PMID: 31806877
DOI: 10.1038/s41416-019-0614-3
PMCID: PMC7028992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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