Article

Gene-Set Enrichment with Mathematical Biology

2019-02-18

Abstract excerpt

Gene-set analyses measure the association between a disease of interest and a set of genes related to a biological pathway. These analyses often incorporate gene network properties to account for the differential contributions of each gene. Extending this concept further, mathematical models of biology can be leveraged to define gene interactions based on biophysical principles by predicting the effects of geneti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 835d8268-182b-5be9-8cea-5380d83aa7fb
DOI: 10.1101/554212

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene-Set Enrichment with Mathematical BiologyDOI 10.1101/554212Read

Gene-set Enrichment with Mathematical Biology (GEMB).Semantic proximity Read

Improved functional mapping with GSA-MiXeR implicates biologically specific gene-sets and estimates enrichment magnitudeSemantic proximity Read

Association weight matrix: a network-based approach towards functional genome-wide association studies.Semantic proximity Read

Genome wide association studies are enriched for interacting genesSemantic proximity Read

On the utility of gene set methods in genomewide association studies of quantitative traits.Semantic proximity Read

BAGSE: a Bayesian hierarchical model approach for gene set enrichment analysisSemantic proximity Read

From GWAS Signals to Molecular Mechanisms: Explainable AI for Causal Gene Prioritization and Biomolecular Target Interpretation.Semantic proximity Read

Application of the parametric bootstrap for gene-set analysis of gene-environment interactions.Semantic proximity Read

PIGNON: A protein-protein interaction-guided functional enrichment analysis for quantitative proteomicsSemantic proximity Read

CLEAR: Concise List Enrichment Analysis Reducing RedundancySemantic proximity Read

Comparison of methods for competitive tests of pathway analysis.Semantic proximity Read

Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder.Semantic proximity Read