Mutational oncogenic signatures on structurally resolved protein interacting interfaces

Abstract excerpt

The importance of the context of interactions in the proteins mutated in cancer is long known. However, our knowledge on how mutations affecting to protein-protein interactions (PPIs) are related to cancer occurrence and progression is still poor. Here, we extracted the missense somatic mutations from 5920 cancer patients of 33 different cancer types, taken from the International Cancer Genome Consortium (ICGC) an...

Topics

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• Biomarkers, Tumor
• Chromosome Mapping
• Computer Simulation
• DNA Mutational Analysis
• Models, Genetic
• Neoplasm Proteins
• Neoplasms
• Protein Interaction Mapping

Identifiers and source

Literature Corpus work

5731dd2d-bfd9-56de-afb7-d29d9b2dc9a1

DOI

10.1101/016204