Article

Mutational oncogenic signatures on structurally resolved protein interacting interfaces

2015-03-07

Abstract excerpt

The importance of the context of interactions in the proteins mutated in cancer is long known. However, our knowledge on how mutations affecting to protein-protein interactions (PPIs) are related to cancer occurrence and progression is still poor. Here, we extracted the missense somatic mutations from 5920 cancer patients of 33 different cancer types, taken from the International Cancer Genome Consortium (ICGC) an...

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Literature Corpus work: 5731dd2d-bfd9-56de-afb7-d29d9b2dc9a1
DOI: 10.1101/016204

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