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cGAS, a DNA Sensor, Promotes Inflammatory Responses in Huntington Disease

2020-01-09

Abstract excerpt

The genetic cause of Huntington disease (HD) is attributed to the N-terminal polyglutamine expansion of huntingtin (mHTT). mHTT, which is a ubiquitously expressed protein, induces noticeable damage to the striatum, which affects motor, psychiatric, and cognitive functions in HD individuals. Although inflammatory responses apparently precede striatal damage and an overall progression of HD, the molecular mechanisms...

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Literature Corpus work
9ffe4647-ded4-5922-baf7-7bcd98246916
DOI
10.1101/2020.01.08.898718
Open publication

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cGAS, a DNA Sensor, Promotes Inflammatory Responses in Huntington DiseaseDOI 10.1101/2020.01.08.898718
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