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Article

Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice.

Nature - 11 Feb 2016

Davies Benjamin, Hatton Edouard, Altemose Nicolas, Hussin Julie G, Pratto Florencia, Zhang Gang, Hinch Anjali Gupta, Moralli Daniela, Biggs Daniel, Diaz Rebeca, Preece Chris, Li Ran, Bitoun Emmanuelle, Brick Kevin, Green Catherine M, Camerini-Otero R Daniel, Myers Simon R, Donnelly Peter

Abstract excerpt

The DNA-binding protein PRDM9 directs positioning of the double-strand breaks (DSBs) that initiate meiotic recombination in mice and humans. Prdm9 is the only mammalian speciation gene yet identified and is responsible for sterility phenotypes in male hybrids of certain mouse subspecies. To investigate PRDM9 binding and its role in fertility and meiotic recombination, we humanized the DNA-binding domain of PRDM9...

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Share to Chromosome Pairing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Genetic Speciation

Share to Histone-Lysine N-Methyltransferase

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Source

Open in PubMed Open full text

Identifiers

PMID: 26840484
DOI: 10.1038/nature16931
PMCID: PMC4756437

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice.PMID 26840484Read ↗

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Beyond the Prdm9 model: independent evolution of hybrid male sterility in house mice.Semantic proximity Read ↗

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