Article

Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2

2023-03-16

Abstract excerpt

A wide range of endogenous and xenobiotic organic ions require facilitated transport systems to cross the plasma membrane for their disposition 1, 2 . In mammals, organic cation transporter subtypes 1 and 2 (OCT1 and OCT2, also known as SLC22A1 and SLC22A2, respectively) are polyspecific transporters responsible for the uptake and clearance of structurally diverse cationic compounds in the liver and kidneys, resp...

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Literature Corpus work: 466915f7-0d91-56d4-9d37-050f300e1ebf
DOI: 10.1101/2023.03.15.532610

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