Article

Structural basis of organic cation transporter-3 inhibition

2022-07-14

Abstract excerpt

Organic cation transporters (OCTs) facilitate the translocation of catecholamines and xenobiotics across the plasma membrane in various tissues throughout the human body. OCT3 plays a key role in low-affinity, high-capacity uptake of monoamines in most tissues including heart, brain and liver. Its deregulation plays a role in diseases. Despite its importance, the structural basis of OCT3 function and its inhibitio...

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Literature Corpus work: 16290714-09ca-582b-95f4-9c6f3adaf511
DOI: 10.1101/2022.07.14.499921

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