Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics.

Pharmacological research - 1 Sept 2016

Wagner David J, Hu Tao, Wang Joanne

Abstract excerpt

Most drugs are intended to act on molecular targets residing within a specific tissue or cell type. Therefore, the drug concentration within the target tissue or cells is most relevant to its pharmacological effect. Increasing evidences suggest that drug transporters not only play a significant role in governing systemic drug levels, but are also an important gate keeper for intra-tissue and intracellular drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Cell Membrane
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Interactions

Share to Genotype

Share to Metformin

Share to Organic Cation Transport Proteins

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27317943
DOI: 10.1016/j.phrs.2016.06.002
PMCID: PMC5293005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics.PMID 27317943Read ↗

Organic cation transporters.Semantic proximity Read ↗

Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences.Semantic proximity Read ↗

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.Semantic proximity Read ↗

Genetic variation in organic cation transporters and considerations in drug development.Semantic proximity Read ↗

Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney.Semantic proximity Read ↗

Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology.Semantic proximity Read ↗

Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter ConsortiumSemantic proximity Read ↗

Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology.Semantic proximity Read ↗

Organic cation transporters.Semantic proximity Read ↗

Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC PerspectiveSemantic proximity Read ↗

Transporter pharmacogenetics: transporter polymorphisms affect normal physiology, diseases, and pharmacotherapy.Semantic proximity Read ↗

The human organic cation transporter OCT1 and its role as a target for drug responsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.