Article

Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scale

2022-07-15

Abstract excerpt

The Organic Anion Transporter 1 is a membrane transporter known for its central role in drug elimination by the kidney. h OAT1 is an antiporter translocating substrate in exchange for α -ketoglutarate. The understanding of h OAT1 structure and function remains limited due to the absence of resolved structure of h OAT1. Benefiting from conserved structural and functional patterns shared with other Major Facilit...

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Literature Corpus work: 25f217c9-43d6-5ced-9b52-fdebdbd14d71
DOI: 10.1101/2022.07.14.500056

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