Article
The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics.
Molecular cell - 16 May 2024
Yee Sook Wah, Macdonald Christian B, Mitrovic Darko, Zhou Xujia, Koleske Megan L, Yang Jia, Buitrago Silva Dina, Rockefeller Grimes Patrick, Trinidad Donovan D, More Swati S, Kachuri Linda, Witte John S, Delemotte Lucie, Giacomini Kathleen M, Coyote-Maestas Willow
Abstract excerpt
Mutations in transporters can impact an individual's response to drugs and cause many diseases. Few variants in transporters have been evaluated for their functional impact. Here, we combine saturation mutagenesis and multi-phenotypic screening to dissect the impact of 11,213 missense single-amino-acid deletions, and synonymous variants across the 554 residues of OCT1, a key liver xenobiotic transporter. By...
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