Article

The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics

2023-06-07

Abstract excerpt

Membrane transporters play a fundamental role in the tissue distribution of endogenous compounds and xenobiotics and are major determinants of efficacy and side effects profiles. Polymorphisms within these drug transporters result in inter-individual variation in drug response, with some patients not responding to the recommended dosage of drug whereas others experience catastrophic side effects. For example, vari...

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Literature Corpus work: 16866f74-8efa-5168-87f7-5791399a8032
DOI: 10.1101/2023.06.06.543963

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